Nuclear receptor structural and molecular pharmacology
How small molecules (endogenous lipids, synthetic ligands, and FDA-approved drugs) change the activity of these therapeutically important transcription factors.
Conformational dynamics and ensembles
How changes in structural motions (dynamics) connect ligand binding to shifting nuclear receptor conformational ensembles and changes in function.
Receptor partnerships
How ligand-dependent nuclear receptor self and partner (heterodimer) interactions create distinct pharmacological responses.
Integrative structural biology to function
We use integrative computational and experimental structure–function methods that connect atomic and molecular insights into cellular function and ligand discovery.