84 publications
Preprints
Manuscripts not yet published in a journal.
bioRxiv · 2026· Preprint
Ileitis abolishes tolerogenic functions of the enterohepatic bile acid pool
Published papers
Journal of structural biology · 2025
Structural insights into IMP2 dimerization and RNA binding
Journal of medicinal chemistry · 2025
Structural Basis of PPARγ-Mediated Transcriptional Repression by the Covalent Inverse Agonist FX-909
Proceedings of the National Academy of Sciences of the United States of America · 2025
A tethering mechanism underlies Pin1-catalyzed proline cis-trans isomerization at a noncanonical site
British journal of pharmacology · 2025
The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors
Structure (London, England : 1993) · 2023
Go big and go home: A bulky extension makes promiscuous ligands settle down
Journal of medicinal chemistry · 2023
Structure-Activity Relationship and Biological Investigation of a REV-ERBα-Selective Agonist SR-29065 (34) for Autoimmune Disorders
Proceedings of the National Academy of Sciences of the United States of America · 2022
Phosphatidylserine orchestrates Myomerger membrane insertions to drive myoblast fusion
Structure (London, England : 1993) · 2021
Structural mechanism underlying ligand binding and activation of PPARγ
Nature chemical biology · 2021
Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling
Journal of medicinal chemistry · 2020
Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1
Proceedings of the National Academy of Sciences of the United States of America · 2019
Quantitative structural assessment of graded receptor agonism
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
The Tat inhibitor didehydro-cortistatin A suppresses SIV replication and reactivation
Journal of medicinal chemistry · 2019
Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone
Structure (London, England : 1993) · 2019
Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1
Cell reports · 2018
REV-ERBα Regulates TH17 Cell Development and Autoimmunity
Nature communications · 2018
A structural mechanism for directing corepressor-selective inverse agonism of PPARγ
Structure (London, England : 1993) · 2018
Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism
Nature communications · 2018
Defining a conformational ensemble that directs activation of PPARγ
Nature communications · 2018
Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements
Structure (London, England : 1993) · 2017
Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA
ACS chemical biology · 2016
Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1
Antimicrobial agents and chemotherapy · 2016
Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication
Proceedings of the National Academy of Sciences of the United States of America · 2016
Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space
Nature communications · 2015
Structural mechanism for signal transduction in RXR nuclear receptor heterodimers
Biochemical pharmacology · 2015
Anti-proliferative actions of a synthetic REV-ERBα/β agonist in breast cancer cells
Nature communications · 2015
Pharmacological repression of PPARγ promotes osteogenesis
The Journal of biological chemistry · 2014
Structure of REV-ERBβ ligand-binding domain bound to a porphyrin antagonist
Nature reviews. Drug discovery · 2014
REV-ERB and ROR nuclear receptors as drug targets
Nature chemical biology · 2013
Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α
Pharmacological reviews · 2013
Nuclear receptors and their selective pharmacologic modulators
Bioorganic & medicinal chemistry letters · 2012
Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα
Bioorganic & medicinal chemistry letters · 2012
Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists
Biomolecular NMR assignments · 2012
¹H, ¹³C and ¹⁵N chemical shift assignments for the human Pitx2 homeodomain in complex with a 22-base hairpin DNA
Structure (London, England : 1993) · 2012
Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism
Nature structural & molecular biology · 2011
DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex
Future medicinal chemistry · 2011
The REV-ERBs and RORs: molecular links between circadian rhythms and lipid homeostasis
Biomolecular NMR assignments · 2011
1H, 13C and 15N chemical shift assignments for the human Pitx2 homeodomain and a R24H homeodomain mutant
ACS chemical biology · 2011
Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist
ACS chemical biology · 2011
Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB
Journal of biomolecular NMR · 2011
Observing selected domains in multi-domain proteins via sortase-mediated ligation and NMR spectroscopy
Current pharmaceutical design · 2011
A role for rev-erbα ligands in regulation of adipogenesis
The Journal of biological chemistry · 2010
Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene
Journal of molecular biology · 2009
Structural and motional contributions of the Bacillus subtilis ClpC N-domain to adaptor protein interactions
Endocrine-related cancer · 2008
Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor
Structure (London, England : 1993) · 2008
Insights into the nature of DNA binding of AbrB-like transcription factors
Biomolecular NMR assignments · 2007
NMR assignment of the N-terminal repeat domain of Bacillus subtilis ClpC
Methods in enzymology · 2007
Classification of response regulators based on their surface properties
Nature structural & molecular biology · 2006
Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D(28K)
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2005
Structural analysis of divalent metals binding to the Bacillus subtilis response regulator Spo0F: the possibility for in vitro metalloregulation in the initiation of sporulation
Journal of the American Chemical Society · 2005
(4,2)D Projection--reconstruction experiments for protein backbone assignment: application to human carbonic anhydrase II and calbindin D(28K)
Journal of molecular biology · 2005
Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing
Biochemical and biophysical research communications · 2003
Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy
The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002
Alternative splicing of a beta4 subunit proline-rich motif regulates voltage-dependent gating and toxin block of Cav2.1 Ca2+ channels
The American journal of pathology · 2001
Three-dimensional imaging of embryonic mouse kidney by two-photon microscopy
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