Bioorganic & medicinal chemistry letters · 2012
Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists
Bioorganic & medicinal chemistry letters, 22(11), 3739-42 (2012)
Abstract
The design and synthesis of a novel series of Rev-erbα agonists is described. The development and optimization of the tetrahydroisoquinoline series was carried out from an earlier acyclic series of Rev-erbα agonists. Through the optimization of the scaffold 1, several potent compounds with good in vivo profiles were discovered.